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Reference type: Journal
Authors: Wang JL, Sibrian-Vazquez M, Escobedo JO, Wang L, Chu YH, Moore RG, Strongin RM
Article Title: Templated polymers enable selective capture and release of lysophosphatidic acid in human plasma via optimization of non-covalent binding to functional monomers.
Publication date: 2015
Journal: Analyst
Volume: 140
Issue: (22)
Page numbers: 7572-7577.
DOI: 10.1039/C5AN01597A

Abstract: The first solid phase extraction materials for selective lysophosphatidic acid (LPA) enrichment from human plasma are described. Molecularly imprinted polymers were designed, synthesized and evaluated as cartridge fillings. They enabled a relatively rapid and simple extraction protocol for LPA without any need for multiple liquid-liquid extraction steps. The five major subspecies of lysophosphatidic acid are readily separated from all other native plasma phospholipids, including those well-known to interfere with LPA quantitation, such as phosphatidylcholine and lysophosphatidylcholine. Outstanding LPA purity is obtained via these solid phase materials in a tandem extraction setup
Template and target information: lysophosphatidic acid, LPA

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