MIPdatabase
Authors: Sharma PS, Wojnarowicz A, Sosnowska M, Benincori T, Noworyta K, D'Souza F, Kutner W
Article Title: Potentiometric chemosensor for neopterin, a cancer biomarker, using an electrochemically synthesized molecularly imprinted polymer as the recognition unit.
Publication date: 2016
Journal: Biosensors and Bioelectronics
Volume: 77
Page numbers: 565-572.
DOI: 10.1016/j.bios.2015.10.013
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0956566315304802
Abstract: With an established procedure of molecular imprinting, a synthetic polymer receptor for the neopterin cancer biomarker was devised and used as a recognition unit of a potentiometric chemosensor. For that, bis-bithiophene derivatized with cytosine and bithiophene derivatized with boronic acid were used as functional monomers. The open-circuit potential (OCP) based transduction under flow-injection analysis conditions (FIA) determined neopterin in the concentration range of 0.15-2.5 mM with the 22 μM limit of detection (LOD) and 7.01(-¦0.15) mV mM-1 sensitivity indicating its potential suitability in clinical analysis applications. The molecularly imprinted polymer (MIP) film showed an appreciable apparent imprinting factor of ~6. The chemosensor successfully discriminated the interferences including the 6-biopterin and pterin structural analogs of neopterin as well as glucose and creatinine. Moreover, it determined neopterin in synthetic serum samples
Template and target information: neopterin
Author keywords: neopterin, Potentiometric chemosensor, molecularly imprinted polymer, Open-circuit potential, Cancer biomarker
Join the Society for Molecular Imprinting
New items RSS feed
View latest updatesSign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.
Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
