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Authors: Han JY, Sun YJ, Hou JP, Wang YY, Liu Y, Xie C, Lu WY, Pan J
Article Title: Preliminary investigations into surface molecularly imprinted nanoparticles for Helicobacter pylori eradication.
Publication date: 2015
Journal: Acta Pharmaceutica Sinica B
Volume: 5
Issue: (6)
Page numbers: 577-582.
DOI: 10.1016/j.apsb.2015.09.003
Alternative URL: http://www.sciencedirect.com/science/article/pii/S2211383515001355
Abstract: This paper reports investigations into the preparation and characterization of surface molecularly imprinted nanoparticles (SMINs) designed to adhere to Helicobacter pylori (H. pylori). Imprinted nanoparticles were prepared by the inverse microemulsion polymerization method. A fraction of Lpp20, an outer membrane protein of H. pylori known as NQA, was chosen as template and modified with myristic acid to facilitate its localization on the surface of the nanoparticles. The interaction between these SMINs with the template NQA were evaluated using surface plasmon resonance (SPR), change in zeta potential and fluorescence polarization (FP). The results were highly consistent in demonstrating a preferential recognition of the template NQA for SMINs compared with the control nanoparticles. In vitro experiments also indicate that such SMINs are able to adhere to H. pylori and may be useful for H. pylori eradication
Template and target information: bacteria, Helicobacter pylori, H. pylori, Lpp20, myristate modified Lpp20, NQA, membrane protein
Author keywords: Surface molecularly imprinted nanoparticles, Epitope imprinting, NQA, Lpp20, Helicobacter pylori binding
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