MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Karfa P, Roy E, Patra S, Kumar D, Madhuri R, Sharma PK
Article Title: A fluorescent molecularly-imprinted polymer gate with temperature and pH as inputs for detection of alpha-fetoprotein.
Publication date: 2016
Journal: Biosensors and Bioelectronics
Volume: 78
Page numbers: 454-463.
DOI: 10.1016/j.bios.2015.11.092
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0956566315306527

Abstract: In this work, we have reported a new approach on the use of stimuli-responsive molecularly imprinted polymer (MIP) for trace level sensing of alpha-fetoprotein (AFP), which is a well know cancer biomarker. The stimuli-responsive MIP is composed of three components, a thermo-responsive monomer, a pH responsive component (tyrosine derivative) and a highly fluorescent vinyl silane modified carbon dot. The synthesized AFP-imprinted polymer possesses excellent selectivity towards their template molecule and dual-stimuli responsive behavior. Along with this, the imprinted polymer was also explored as 'OR' logic gate with two stimuli (pH and temperature) as inputs. However, the non-imprinted polymers did not have such 'OR' gate property, which confirms the role of template binding. The imprinted polymer was also used for estimation of AFP in the concentration range of 3.96-80.0 ng mL-1, with limit of detection (LOD) 0.42 ng mL-1. The role of proposed sensor was successfully exploited for analysis of AFP in real human blood plasma, serum and urine sample
Template and target information: protein, alpha-fetoprotein, α-fetoprotein
Author keywords: Molecular gate, Stimuli-responsive polymer, Fluorescence sensor, molecularly imprinted polymer, Alpha-fetoprotein


  Scandium periodic table greetings card  Scientist peptide mug  I shop perodically customisable tote bag

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner