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Reference type: Journal
Authors: Wu ZH, Hou JP, Wang YY, Chai ML, Xiong Y, Lu WY, Pan J
Article Title: Preparation and evaluation of amoxicillin loaded dual molecularly imprinted nanoparticles for anti-Helicobacter pylori therapy.
Publication date: 2015
Journal: International Journal of Pharmaceutics
Volume: 496
Issue: (2)
Page numbers: 1006-1014.
DOI: 10.1016/j.ijpharm.2015.10.065
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0378517315303331

Abstract: This paper reports studies on preparation and evaluation of amoxicillin loaded dual molecularly imprinted nanoparticles (Amo/Dual-MIPs) designed for anti-H. pylori therapy. Both MNQA and AmoNa were chosen as templates to prepare Dual-MIPs using inverse microemulsion polymerization method. NQA was modified with myristic acid (MNQA) to become amphiphilic and assist in leaving NQA cavities on the surface of Dual-MIPs for H. pylori adhesion. AmoNa was applied to produce imprinting sites in Dual-MIPs for rebinding AmoNa to exert its anti-H. pylori effect. Batch rebinding test demonstrated a preferential rebinding effect of NQA toward the Dual-MIPs. In vivofluorescence imaging showed the prolonged residence time of Dual-MIPs in H. pylori infected mice stomachs after intragastric administration of nanoparticles.In vivo H. pylori clearance tests indicated Amo/Dual-MIPs had a better aniti-H. pylori effect than amoxicillin powder did. In conclusion, Amo/Dual-MIPs may provide an alternative drug delivery strategy for anti-H. pylori therapy
Template and target information: amoxicillin, Amo, AmoNa, bacteria, Helicobacter pylori, H. pylori, Lpp20, myristate modified Lpp20, NQA, membrane protein
Author keywords: Dual molecularly imprinted nanoparticles, Lpp20, Amoxicillin sodium, Template rebinding, anti-H.pylori therapy


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