MIPdatabase
Authors: Sheykhaghaei G, Hossainisadr M, Khanahmadzadeh S, Seyedsajadi M, Alipouramjad A
Article Title: Magnetic molecularly imprinted polymer nanoparticles for selective solid phase extraction and pre-concentration of Tizanidine in human urine.
Publication date: 2016
Journal: Journal of Chromatography B
Volume: 1011
Page numbers: 1-5.
DOI: 10.1016/j.jchromb.2015.12.013
Alternative URL: http://www.sciencedirect.com/science/article/pii/S1570023215303378
Abstract: In this work, the magnetic molecularly imprinted polymer nanoparticles (MMIP-NPs) for the selective pre-concentration of Tizanidine have been described. The polymer nanoparticles were synthesized by the polymerization of methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, 2,2-azobisisobutyronitrile as an initiator and Tizanidine as a template molecule. The MMIP-NPs were characterized by scanning electron microscopy (SEM) and thermogravimeteric analysis (TGA). Imprinted Tizanidine molecules were removed from the polymeric structure using acetic acid in methanol (10:90 V/V%), as the eluent solvent. The limits of detection (L.O.D) for Tizanidine were 1.13 x 10-6 M and 1.68 x 10-6 M in ultrapure water and urine, respectively. Also, the relative standard deviations (R.S.D) in ultrapure water and urine were 2.21% and 2.58%, respectively. The method was applied to the determination of Tizanidine in the human urine samples
Template and target information: tizanidine
Author keywords: magnetic nanoparticles, molecularly imprinted polymer, Magnetic solid phase extraction (MSPE), Ttizanidine, human urine
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