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Reference type: Journal
Authors: Ma JB, Qiu HW, Rui QH, Liao YF, Chen YM, Xu J, Zhan PP, Zhao YG
Article Title: Fast determination of catecholamines in human plasma using carboxyl-functionalized magnetic-carbon nanotube molecularly imprinted polymer followed by liquid chromatography-tandem quadrupole mass spectrometry.
Publication date: 2016
Journal: Journal of Chromatography A
Volume: 1429
Page numbers: 86-96.
DOI: 10.1016/j.chroma.2015.12.030
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0021967315017999

Abstract: A novel, simple and sensitive method based on the use of dispersive micro-solid-phase extraction (d-μ-SPE) procedure combined with ultra-fast liquid chromatography-tandem quadrupole mass spectrometry (UFLC-MS/MS) for the determination of catecholamines, i.e., dopamine (DA), norepinephrine(NE) and epinephrine (E), was developed and validated. The novel catecholamines molecularly imprinted polymer (MIP) on the surface of carboxyl-functionalized magnetic-carbon nanotube (CF@m-CNTs-MIP) was synthesized and characterized by vibrating sample magnetometer (VSM), scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The CF@m-CNTs-MIP was used as the d-μ-SPE sorbent to extract catecholamines from human plasma samples. The obtained results demonstrated the higher extraction capacity of CF@m-CNTs-MIP with recoveries between 87.5-110%. The limits of quantification (LOQs) for NE, E and DA were 76 ng/L, 18 ng/L and 10 ng/L, respectively. Validation results on linearity, specificity, accuracy, precision and stability, as well as on application to the analysis of catecholamines in 120 healthy volunteers demonstrated the applicability to clinical studies
Template and target information: catecholamines, dopamine, DA, norepinephrine, NE, epinephrine, E, adrenaline
Author keywords: Liquid chromatography-tandem quadrupole mass spectrometry (LC-MS, MS), Dispersive micro-solid-phase extraction (d-μ-SPE), dopamine, Norepinephrine, epinephrine, human plasma


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