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Reference type: Journal
Authors: Thanh NTK, Rathbone DL, Billington DC, Hartell NA
Article Title: Selective recognition of cyclic GMP using a fluorescence-based molecularly imprinted polymer.
Publication date: 2002
Journal: Analytical Letters
Volume: 35
Issue: (15)
Page numbers: 2499-2509.
DOI: 10.1081/AL-120016540
Alternative URL: http://www.informaworld.com/10.1081/AL-120016540

Abstract: Guanosine 3',5'-cyclic monophosphate (cGMP) plays a role as a second messenger in many different biological systems. Given the ubiquitous nature of cGMP, a simple method of detecting cGMP is of interest. To that end a fluorescent polymer with recognition sites for cGMP has been prepared. Its selectivity and sensitivity were investigated and a dose-dependant decrease in fluorescence of the polymer in the presence of cGMP was observed. In contrast, virtually no effect was detected upon application of the structurally similar molecules, guanosine 5'-monophosphate (GMP) and adenosine 3',5'- cyclic monophosphate (cAMP), thus demonstrating the high selectivity of this polymer. The association constant for the binding of cGMP to the imprinted polymer was determined in order of 3 x 10(5) M-1. A fluorescent, molecularly imprinted polymer that selectively recognises cGMP may have a useful application as a fluorescent chemosensor for cGMP detection in biological samples
Template and target information: guanosine 3',5'-cyclic monophosphate, cGMP

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