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Reference type: Journal
Authors: Lee MH, Thomas JL, Chen JZ, Jan JS, Lin HY
Article Title: Activation of tumor suppressor p53 gene expression by magnetic thymine-imprinted chitosan nanoparticles.
Publication date: 2016
Journal: Chemical Communications
Volume: 52
Issue: (10)
Page numbers: 2137-2140.
DOI: 10.1039/C5CC09896C

Abstract: Chitosan is a natural biodegradable polysaccharide that has been used to enhance gene delivery, owing to the ease with which chitosan nanoparticles enter the nucleus of cells. To study the effects of nuclear delivery of telomeric gene sequences, which contain thymine, we formed magnetic thymine-imprinted chitosan nanoparticles (TIPs) by the precipitation of chitosan, mixed with thymine and magnetic nanoparticles (to aid in separations). The mean size of the TIPS was 116 � 18 nm; the dissociation constant for thymine was 21.8 mg mL-1. We then treated human hepatocellular carcinoma (HepG2) with TIPs nanoparticles bearing bound thymine or a bound telomeric DNA sequence. The expression of the tumor suppressor p53 gene increased when TIPs were applied and decreased when telomere-bound TIPs were applied
Template and target information: thymine

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