Authors: Tomioka Y
, Kudo Y
, Hayashi T
, Nakamura H
, Niizeki M
, Hishinuma T
, Mizugaki M
Phenobarbital molecularly imprinted polymer selectively binds phenobarbital.
Publication date: 1997
Journal: Biological & Pharmaceutical Bulletin
Alternative URL: https://www.jstage.jst.go.jp/article/bpb1993/20/4/20_4_397/_article
Abstract: Molecularly imprinted polymer (MIP) was prepared against phenobarbital using methacrylic acid as the functional monomer and ethylene glycol dimethacrylate as the cross linking monomer. We analyzed the recognition properties of the phenobarbital MIP. In some organic solvents, imprinted polymer showed selective binding to phenobarbital. Two dissociation constants of binding were calculated by Scatchard plot analyses; K-d values were 1.8, 121.7 μM, and the number of binding sites was 8.3, 92.3 μmol/g MIP in toluene- heptane-acetic acid (25:75:1, v/v), respectively. The relationship between the binding affinity to phenobarbital MIP and the polarity of the solvent system, as well as the structure of the template molecule is also discussed
Template and target information: phenobarbital
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