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Reference type: Book Chapter
Authors: Maximilien J, Beyazit S, Rossi C, Haupt K, Tse Sum Bui B
Publication date: 2016
Chapter title: Nanoparticles in Biomedical Applications.
Page numbers: 177-210.
DOI: 10.1007/11663_2015_12

Book title: Measuring Biological Impacts of Nanomaterials
Editors: Wegener J
Publisher: Springer International Publishing
City: Cham
ISBN: 978-3-319-24823-3
Series title: Bioanalytical Reviews

Abstract: Due to readily adaptive sizes, shapes, compositions and large surface area to volume ratios, nanoparticles (NPs) are increasingly prevalent in biomedical applications. In recent times, a plethora of NPs have been investigated specifically regarding how they can be exploited for drug delivery, bioimaging agents and theranostic tools. In this article, lipid-based, inorganic, dendrimeric and polymeric nanoparticles serving these applications are described. The ease of synthesis of these NPs, coupled with an enhanced stability, reduced toxicity and ability to conjugate with diverse molecules (peptides, proteins, antibodies, aptamers) for biocompatibility and biotargeting, indicates that all the key components are being met for their advances towards approved therapies. For their successful applications as drug delivery systems, smart polymeric NPs responding to stimuli such as heat, pH and light to provide controlled release have been introduced. Upconverting nanoparticles and molecularly imprinted polymers, often termed plastic antibodies because of their high affinity and selectivity towards their target molecules, are further discussed as novel bioimaging materials
Template and target information: Review - nanoparticles in biomedical applications
Author keywords: drug delivery, Molecularly imprinted polymers, nanoparticles, Theranostics, Smart materials


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