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Reference type: Journal
Authors: Abdulla NI, Yaseen HM
Article Title: Potentiometric Transducers for the Selective Recognition of Risperidone Based on Molecularly Imprinted Polymer.
Publication date: 2015
Journal: Iraqi Journal of Pharmaceutical Science
Volume: 24
Issue: (2)
Page numbers: 30-40.
Alternative URL: http://bijps.com/LionImages/News/30-40.pdf

Abstract: Graphite Coated Electrodes (GCE) based on molecularly imprinted polymers were fabricated for the selective potentiometric determination of Risperidone (Ris). The molecularly imprinted (MIP) and nonimprinted (NIP) polymers were synthesized by bulk polymerization using (Ris.) as a template, acrylic acid (AA) and acrylamide (AAm) as monomers, ethylene glycol dimethacrylate (EGDMA) as a cross-linker and benzoyl peroxide (BPO) as an initiator. The imprinted membranes and the non-imprinted membranes were prepared using dioctyl phthalate (DOP) and Dibutylphthalate (DBP) as plasticizers in PVC matrix. The membranes were coated on graphite electrodes. The MIP electrodes using (AA) and (AAm) showed a near nernstian and nernstian response with slopes of 55.2 0.1 and 59.0 0.2 mV/decade, correlation coefficient (r2) 0.9997 and 0.9999, a linear response for a concentration range of (1.0 x 10-6 - 1.0 x 10-2) M and (5.0 x 10-7 to 1.0 x 10-2) M respectively. The response time of the prepared electrodes was less than 30 seconds. The electrode responses were stable in a pH range (4-8). The electrodes exhibited good selectivity over a wide range of interference. The most effective electrode (Ris-MIP GCE) was used to determine the concentration of (Ris.) in some pharmaceutical formulations. The electrodes could be successfully used within (7 and 13) weeks respectively without any drift.
Template and target information: risperidone, Ris
Author keywords: ion-selective electrodes, molecularly imprinted polymer, PVC membrane coated graphite electrode, Risperidone

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