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Reference type: Journal
Authors: Ornelas M, Azenha M, Ara˙jo MJ, Marques EF, Dias-Cabral AC, Pereira C, Silva AF
Article Title: Acylated-naproxen as the surface-active template in the preparation of micro- and nanospherical imprinted xerogels by emulsion techniques.
Publication date: 2016
Journal: Journal of Chromatography A
Volume: 1437
Page numbers: 107-115.
DOI: 10.1016/j.chroma.2016.01.074
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0021967316300619

Abstract: A strategy based on water-in-oil emulsion for the dispersion of a sol-gel mixture into small droplets was employed with the view of the production of naproxen-imprinted micro- and nanospheres. The procedure, aiming at a surface imprinting process, comprised the synthesis of a naproxen-derived surfactant. The imprinting process occurred at the interface of the emulsions or microemulsions, by the migration of the NAP-surfactant head into the sol-gel drops to leave surficial imprints due mainly to ion-pair interaction with a cationic group contained within the growing sol-gel network. The surface-imprinted microspheric particles exhibited a log-normal size distribution with geometric mean diameter of 3.1 μm. A mesoporous texture was found from measurements of the specific surface area (206 m2/g) and pore diameter (Dp 2 nm). Evaluation of the microspheres as packed HPLC stationary phases resulted in the determination of the selectivity factor against ibuprofen (α = 2.1), demonstrating the successful imprinting. Chromatographic efficiency, evaluated by the number of theoretical plates (222 plates cm-3), emerged as an outstanding feature among the set of all relatable formats produced before, an advantage intrinsic to the location of the imprinted sites on the surface. The material presented a capacity of 3.2 μmol g-1. Additionally, exploratory work conducted on their nanoscale counterparts resulted in the production of nanospheres in the size order of 10 nm providing good indications of a successful imprinting process
Template and target information: 2-(6-methoxy-5-tetradecanoylnaphth-2-yl) propanoate, 5-C14-NAP, acylated naproxxen, naproxen, NAP
Author keywords: surface imprinting, Acylated-naproxen, Silica microspheres, Silica Nanospheres, sol-gel, W, O emulsion

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