MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Ornelas M, Azenha M, Ara˙jo MJ, Marques EF, Dias-Cabral AC, Pereira C, Silva AF
Article Title: Acylated-naproxen as the surface-active template in the preparation of micro- and nanospherical imprinted xerogels by emulsion techniques.
Publication date: 2016
Journal: Journal of Chromatography A
Volume: 1437
Page numbers: 107-115.
DOI: 10.1016/j.chroma.2016.01.074
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0021967316300619

Abstract: A strategy based on water-in-oil emulsion for the dispersion of a sol-gel mixture into small droplets was employed with the view of the production of naproxen-imprinted micro- and nanospheres. The procedure, aiming at a surface imprinting process, comprised the synthesis of a naproxen-derived surfactant. The imprinting process occurred at the interface of the emulsions or microemulsions, by the migration of the NAP-surfactant head into the sol-gel drops to leave surficial imprints due mainly to ion-pair interaction with a cationic group contained within the growing sol-gel network. The surface-imprinted microspheric particles exhibited a log-normal size distribution with geometric mean diameter of 3.1 μm. A mesoporous texture was found from measurements of the specific surface area (206 m2/g) and pore diameter (Dp 2 nm). Evaluation of the microspheres as packed HPLC stationary phases resulted in the determination of the selectivity factor against ibuprofen (α = 2.1), demonstrating the successful imprinting. Chromatographic efficiency, evaluated by the number of theoretical plates (222 plates cm-3), emerged as an outstanding feature among the set of all relatable formats produced before, an advantage intrinsic to the location of the imprinted sites on the surface. The material presented a capacity of 3.2 μmol g-1. Additionally, exploratory work conducted on their nanoscale counterparts resulted in the production of nanospheres in the size order of 10 nm providing good indications of a successful imprinting process
Template and target information: 2-(6-methoxy-5-tetradecanoylnaphth-2-yl) propanoate, 5-C14-NAP, acylated naproxxen, naproxen, NAP
Author keywords: surface imprinting, Acylated-naproxen, Silica microspheres, Silica Nanospheres, sol-gel, W, O emulsion


  Template of Doom spoof movie poster bag  Chemistry peptide mug  Chemists are fun customisable shirt

Molecules Special Issue call      Appeal for information






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon