MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Abedi M, Shirvani-Arani S, Nabid MR, Bahrani-Samani A
Article Title: Synthesis and characterization of a novel acryl amide-based yttrium imprinted sorbent via the ATRP approach for the preparation of medical-grade 90Y.
Publication date: 2016
Journal: Radiochimica Acta
Volume: 104
Issue: (2)
Page numbers: 117-129.
DOI: 10.1515/ract-2015-2400
Alternative URL: http://www.degruyter.com/view/j/ract.2016.104.issue-2/ract-2015-2400/ract-2015-2400.xml?format=INT

Abstract: Because of its favorable radionuclidic properties (pure beta emitter, Eβmax = 2.28 MeV, T1/2 = 64.1 h), the preparation of carrier free 90Y is of a great importance in radiopharmacy. Herein, we report the synthesis, characterization, and application of a novel yttrium sorbent prepared on the basis of the ion-imprinting concept. The ion-imprinted polymer (IIP) was prepared by atom transfer radical copolymerization of acryl amide (AAm, functional monomer) and N,N'-methylenebisacrylamide (MBAAm) crosslinking agent in the presence of a complex of yttrium ions (template ions) with a homemade chelator, i.e., 2,2-bis(2-bromo-2-methylpropanoate)propane-1,3-disuccinate (also as initiator). For elimination of yttrium ions, which act as the template, the prepared particles were treated with 50% v:v HCl : H2O to produce yttrium-imprinted polymeric sorbent. To control the imprinting effect, corresponding non-imprinted particles (NIP) were prepared in a similar manner except that yttrium ions were not used. The synthesized chemicals for the preparation of the chelator-initiator compound and the product itself were assessed in every step using 1H-NMR analysis. NIP and YIP were subjected to X-ray diffraction (XRD), infra-red spectroscopy (IR) and BET surface area analysis for characterization studies. Sorption/desorption studies were conducted, and the effects of potentially interfering ions, such as Sr2+ (α = 119.69) and Zr4+ (α = 73.01) in presence of radio-yttrium, were investigated (particle size: 50-100 μm, resultant recovery of > 99% within 60 min and a capacity of 33.33 mg Y(III) per gram of sorbent). The results showed that amounts of radio-yttrium as low as 250 μg could be extracted effectively with high radionuclidic and radiochemical purity from macro-gram amounts of strontium.
Template and target information: yttrium ion, 90Y, Y(III)
Author keywords: Carrier free yttrium-90, Ion-imprinted polymer, purification, solid phase extraction

  Periodic table Trainer shirt  Life Science peptide mug  We need to talk about Kelvin shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner