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Reference type: Journal
Authors: Wang SS, Yin DY, Wang WJ, Shen XJ, Zhu JJ, Chen HY, Liu Z
Article Title: Targeting and Imaging of Cancer Cells via Monosaccharide-Imprinted Fluorescent Nanoparticles.
Publication date: 2016
Journal: Scientific Reports
Volume: 6
Page numbers: ArticleNo22757.
DOI: 10.1038/srep22757

Abstract: The recognition of cancer cells is a key for cancer diagnosis and therapy, but the specificity highly relies on the use of biorecognition molecules particularly antibodies. Because biorecognition molecules suffer from some apparent disadvantages, such as hard to prepare and poor storage stability, novel alternatives that can overcome these disadvantages are highly important. Here we present monosaccharide-imprinted fluorescent nanoparticles (NPs) for targeting and imaging of cancer cells. The molecularly imprinted polymer (MIP) probe was fluorescein isothiocyanate (FITC) doped silica NPs with a shell imprinted with sialic acid, fucose or mannose as the template. The monosaccharide-imprinted NPs exhibited high specificity toward the target monosaccharides. As the template monosaccharides used are over-expressed on cancer cells, these monosaccharide-imprinted NPs allowed for specific targeting cancer cells over normal cells. Fluorescence imaging of human hepatoma carcinoma cells (HepG-2) over normal hepatic cells (L-02) and mammary cancer cells (MCF-7) over normal mammary epithelial cells (MCF-10A) by these NPs was demonstrated. As the imprinting approach employed herein is generally applicable and highly efficient, monosaccharide-imprinted NPs can be promising probes for targeting cancer cells
Template and target information: monosaccharides, sialic acid, fucose, mannose
Author keywords: Fluorescent probes, nanoparticles


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