Abstract: Molecular imprinting, which is a technique for preparing synthetic polymers containing specific recognition sites and is particularly useful for enantiomeric separation is gaining increasing importance. In the present study substrate selective polymers were prepared by using D-mandelic acid as the print molecule, acrylamide and 4-vinyl pyridine as the functional monomers which is believed to interact both ionically and through hydrogen bonding with the print molecule. Ethylene glycol dimethacrylate (EGDMA) and divinyl benzene (DVB) were used as the crosslinking agents. The specific rebinding ability of the imprinted polymers were investigated spectrophotometrically and compared with non-imprinted polymers. Imprinted polymers have rebinding capacity than the non-imprinted polymers. The dependence of concentration, solvent, time, and mass on the selective rebinding has been investigated. The selective rebinding ability of these polymers towards the print molecule and enantioselectivity were also investigated.
Template and target information: mandelic acid, d-mandelic acid
Author keywords: imprinting, Specific recognition sites, enantiomeric separation, Rebinding