MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Gutiérrez-Climente R, Gómez-Caballero A, Unceta N, Aránzazu Goicolea M, Barrio RJ
Article Title: A new potentiometric sensor based on chiral imprinted nanoparticles for the discrimination of the enantiomers of the antidepressant citalopram.
Publication date: 2016
Journal: Electrochimica Acta
Volume: 196
Page numbers: 496-504.
DOI: 10.1016/j.electacta.2016.03.010
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0013468616305242

Abstract: In this work, the development of a novel enantioselective sensor is described using chiral imprinted nanoparticles as recognition elements. Imprinted nanoparticles, synthesised via precipitation polymerisation, were incorporated in a polyvinyl chloride membrane which served as the sensing element to construct a potentiometric sensor selective to the S enantiomer of the antidepressant drug citalopram (SCIT). The effect of the amount of nanoparticles, the type and quantity of plasticiser and the concentration of the internal reference solution were assessed in order to have a sensor with best sensor performance. The fabricated sensor showed Nernstian behaviour with a slope of 50.77 ± 1.32 mV decade-1 in SCIT+ solutions that ranged from 2.5 x 10-7 to 10-3 mol L-1. Sensor applicability to urine samples was also tested using spiked urine samples as quality control samples as well as urine collected from a volunteer who had been treated with this drug. The fabricated sensor was capable of accurately determining SCIT+ with good precision (RSD 2.07-6.56%) at different concentration levels
Template and target information: citalopram, SCIT
Author keywords: Potentiometry, Enantioselective sensor, S-citalopram, precipitation polymerisation, molecularly imprinted polymer

  Keyring featuring the name Ramon spelled out in symbols of the chemical elements  Scientist peptide mug  I shop perodically customisable tote bag

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner