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Abstract: This article describes a method for determination of four aflatoxins by a combination of ultra-high performance liquid chromatography and mass spectrometry (UHPLC-MS/MS). Magnetic dummy molecularly imprinted polymers (md-MIPs) are used for fairly selective preconcentration. The preparation of the md-MIP involves (a) coating of magnetic nanoparticles (with a typical diameter of 200 nm) with a shell of silica, (b) modifying the surface with methacryloxy groups, and (c) creating a MIP on the surface by graft imprinting in aqueous solutions using 5,7-dimethoxycoumarin as the dummy template, and methacrylic acid and 4-vinylpyridine as the functional monomers. After elution of the template, the md-MIPs can be used for fairly selective extraction of the aflatoxins B1, B2, G1 and G2. Following magnetic separation of the particles, the aflatoxins were eluted and quantified by UHPLC-MS/MS. The limit of detection is 0.05 μg kg-1 for aflatoxins B2 and G2, and 0.1 μg kg-1 for aflatoxins B1 and G1. False-positive samples were identified by UHPLC-MS/MS in the positive ionization mode with multiple reaction monitoring
Template and target information: aflatoxins, aflatoxin B1, aflatoxin B2, aflatoxin G1, aflatoxin G2
Author keywords: nanomaterial, MIP, Vibrating magnetometry, Saturation magnetization, transmission electron microscopy, core-shell particles, UHPLC-MS, MS, FTIR, food analysis