Abstract: In this paper a new electrochemical sensor based on molecularly imprinted polymer immobilized on multiwall carbon nanotube surface was introduced for determination of ceftazidime. The sensor was constructed via synthesis of a molecularly imprinted polymer on glassy carbon electrode which has been modified with carboxyl-functionalized multiwall carbon nanotubes. Then, for increasing the sensitivity of the sensor, Ag dendrites (AgDs) nanobranch was deposited on polymer electrochemically. The resulting imprinted polymer-multiwall carbon nanotube composite showed high sensitivity, excellent stability and good specific recognition behavior towards template molecule. The morphology of AgDs/MIP/c-MWCNT/GCE was investigated by field emission scanning electron microscopy, cyclic voltammetry and electrochemical impedance spectroscopy in detail. Under the optimal experimental conditions, the current response of the imprinted sensor was linear to the concentration of ceftazidime in the range of 2-500 and 500-7000 nM, with the limit of detection of 0.55 nM (S/N = 3). The proposed sensor has also been examined for recognition of ceftazidime quantitatively, in complicated matrices real samples
Template and target information: ceftazidime
Author keywords: Ceftazidime, molecularly imprinted polymer, Multiwall carbon nanotubes, Ag dendrites