Reference type: Journal
Authors: Arabi M, Ostovan A, Ghaedi M, Purkait MK
Article Title: Novel strategy for synthesis of magnetic dummy molecularly imprinted nanoparticles based on functionalized silica as an efficient sorbent for the determination of acrylamide in potato chips: Optimization by experimental design methodology.
Publication date: 2016
Journal: Talanta
Volume: 154
Page numbers: 526-532.
DOI: 10.1016/j.talanta.2016.04.010
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0039914016302491

Abstract: This study discusses a novel and simple method for the preparation of magnetic dummy molecularly imprinted nanoparticles (MDMINPs). Firstly, Fe3O4 magnetic nanoparticles (MNPs) were synthesized as a magnetic component. Subsequently, MDMINPs were constructed via the sol-gel strategy using APTMS as the functional monomer. Urethane was considered as dummy template to avoid residual template and TEOS as the cross linker. The prepared MDMINPs were used for the pre-concentration of acrylamide from potato chips. Quantification was carried out by high performance liquid chromatography with UV detection (HPLC-UV). The impact of influential variables such as pH, amount of sorbent, sonication time and eluent volume were well investigated and optimized using a central composite design. The particles had excellent magnetic property and high selectivity to the targeted molecule. In optimized conditions, the recovery ranged from 94.0% to 98.0% with the detection limit of 0.35 μg kg-1
Template and target information: urethane, dummy template, acrylamide
Author keywords: molecularly imprinted, dummy template, Functionalized silica, magnetic nanoparticles, acrylamide, Experimental design