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Abstract: In this study, we report the synthesis of MIP-coated hybrid NPs by "semi-covalent" imprinting technique throught a thermally reversible covalent bond and application for biochemical separation of β-estradiol (E2). A moleculary imprinted polymer (MIP) were synthesized using 3-(triethoxysilyl) propyl isocyanate and dibutyltin dilanurate as a functional monomer and cross-linking agent and β-estradiol as template. The removal of the template by a simple thermal reaction produced specific β-estradiol recognition sites on the surface of silica shell. Meanwhile, a solid-phase extraction (SPE) based on E2- MMIPs has been established for efficient separation and fast enrichment of E2 from the plasma. Recoveries of E2 from two kinds of plasma spiked at different concentration levels ranged from 86.9 to 103.3 with RSD <1.76 %.In this manner LOD was 0.0019 and LOQ was 0.0057 (μmol L-1), capacity factor and selectivity factor were 3.05 and 1.099 respectively. Also E2- MMIPs was used for selective separation of E2 from drugs mixture
Template and target information: β-estradiol, E2
Author keywords: β-estradiol, Magnetic molecularly imprinted, Fe3O4@SiO2, Electronic