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Reference type: Journal
Authors: dos Santos PM, Hall AJ, Manesiotis P
Article Title: Stoichiometric molecularly imprinted polymers for the recognition of anti-cancer pro-drug tegafur.
Publication date: 2016
Journal: Journal of Chromatography B
Volume: 1021
Page numbers: 197-203.
DOI: 10.1016/j.jchromb.2015.12.015
Alternative URL: http://www.sciencedirect.com/science/article/pii/S1570023215303408

Abstract: Molecularly imprinted polymers (MIPs) targeting tegafur, an anti-cancer 5-fluorouracil pro-drug, have been prepared by stoichiometric imprinting using 2,6-bis(acrylamido)pyridine (BAAPy) as the functional monomer. Solution association between tegafur and BAAPy was studied by 1H NMR titration, which confirmed the formation of 1:1 complexes with an affinity constant of 574 15 M-1 in CDCl3. Evaluation of the synthesised materials by HPLC and equilibrium rebinding experiments revealed high selectivity of the imprinted polymer for the pro-drug vs. 5-fluorouracil and other competing analytes, with maximum imprinting factors of 25.3 and a binding capacity of 45.1 μmol g-1. The synthesised imprinted polymer was employed in solid-phase extraction of the pro-drug using an optimised protocol that included a simple wash with the porogen used in the preparation of the material. Tegafur recoveries of up to 96% were achieved from aqueous samples and 92% from urine samples spiked with the template and three competing analytes. The results demonstrate the potential of the prepared polymers in the pre-concentration of tegafur from biological samples, which could be an invaluable tool in the monitoring of patient compliance and drug uptake and excretion
Template and target information: tegafur
Author keywords: Tegafur, 5-fluorouracil, bioanalysis, Molecularly imprinted polymers, Solid-phase extraction


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