MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Goud KY, M S, Reddy KK, Gobi KV
Article Title: Development of highly selective electrochemical impedance sensor for detection of sub-micromolar concentrations of 5-Chloro-2,4-dinitrotoluene.
Publication date: 2016
Journal: Journal of Chemical Sciences
Volume: 128
Issue: (5)
Page numbers: 763-770.
DOI: 10.1007/s12039-016-1078-0

Abstract: A highly selective and sensitive impedimetric sensor based on molecular imprinted polymer (MIP) has been developed for the detection of 5-chloro-2,4-dinitrotoluene (5CDNT). Computational simulations were carried out for the best combinations of MIP precursors by using Hyperchem software. MIP of 5CDNT is synthesized using the optimized combinations of polymer precursors such as the functional monomer and cross-linker. Synthesized MIP and non-imprinted polymer (NIP) were characterized by Fourier transform infrared spectroscopy (FT-IR) and BET adsorption isotherm analysis. The surface area and pore volume of MIP are quite high compared to that of NIP, while the average pore diameter of MIP is lower than that of NIP. However, the synthesized MIP with high surface area and quite good pore diameter for free flow of analytes is suitable for efficient binding with the analyte 5CDNT. Binding assay studies of MIP by using UV-Visible spectroscopy showed that the molecular imprinting factor is nearly thrice to that of NIP. Carbon paste electrodes incorporated with MIP were employed as a sensor for 5CDNT by applying electrochemical impedance spectroscopy (EIS) as transduction principle. The charge transfer resistance obtained by impedimetric analysis is proportional to the concentration of 5CDNT over a wide concentration range: 10 nM to 100 μM. A linear determination range of 1.0 to 100 μM was obtained, and the low-detection-limit was found to be 0.1 μM. The MIP carbon paste electrode has shown very good selectivity towards specific recognition of 5CDNT despite the coexistence of possible interferents like 2,4-dinitrotoluene and 1,3-dinitrobenzene. The present MIP based sensor system could be used successfully for direct determination of 5CDNT
Template and target information: 5-chloro-2,4-dinitrotoluene, 5CDNT
Author keywords: 5-Chloro-2 4-dinitrotoluene, combinatorial studies, molecular imprinted polymers, FT-IR spectroscopy, binding assay, electrochemical impedance spectroscopy


  Periodic table Trainer shirt  PhD Scientist peptide mug  We need to talk about Kelvin shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner