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Reference type: Journal
Authors: Aikio S, Zeilinger M, Hiltunen J, Hakalahti L, Hiitola-Keinanen J, Hiltunen M, Kontturi V, Siitonen S, Puustinen J, Lieberzeit P, Karioja P
Article Title: Disposable (bio)chemical integrated optical waveguide sensors implemented on roll-to-roll produced platforms.
Publication date: 2016
Journal: RSC Advances
Volume: 6
Issue: (56)
Page numbers: 50414-50422.
DOI: 10.1039/C6RA07320D

Abstract: To enable wide spread dissemination of sensors in cost-critical applications and resource poor settings, methods to implement sensor chips using low-cost materials and mass-manufacturing methods are developed. In this paper we demonstrate that disposable polymeric integrated Young interferometer (YI) sensor chips, implemented on roll-to-roll mass-manufactured waveguides, are applicable for analyte specific sensing of small molecules and for multi-analyte detection of biomolecules. For the chemical sensing of small molecules, a sensor chip was functionalized with a molecularly imprinted polymer (MIP). We demonstrate that the MIP receptor layer is compatible with a polymer-based evanescent wave sensor for direct refractive index sensing. For multi-analyte detection of biomolecules, antibody-based receptor layers were patterned by inkjet printing onto the sensor surface demonstrating the applicability of the method with integrated YI chips. Demonstration of the analyte specific chemical- and biosensing with disposable polymeric YI sensor chips opens new possibilities to implement low-cost (bio)chemical sensors
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