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Abstract: A simple methodology was used to develop a novel sensor based on a core-shell/molecularly imprinted polymer (MIP) for the determination of ephedrine. The Fe3O4@SiO2@TiO2-MIP nanocomposite with a well-defined core-shell structure was synthesized using a simple imprinting strategy. The morphology of the synthesized nanocomposite was observed by scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and the properties of the sensor were examined by cyclic voltammetry and electrochemical impedance spectroscopy. The fabricated electrochemical sensor based on the Fe3O4@SiO2@TiO2-MIP nanocomposite exhibits great features such as a remarkably low detection limit of 0.0036 μmol L-1 (3Sb/m), superb selectivity in discriminating ephedrine from its structural analogues and good anti-interference ability towards several co-existing substances. Also, it was used to detect the concentration of ephedrine in the linear range of 0.0090-2.8 μmol L-1. Moreover, the proposed method demonstrates excellent repeatability and stability, with a relative standard deviation (RSD) of less than 1.4% and 1.6%, respectively. Analysis of ephedrine in pharmaceutical dosage forms and biological fluids is successfully carried out without the assistance of complicated pretreatment. The Fe3O4@SiO2@TiO2-MIP nanocomposite presented here with admirable merits makes it a promising candidate for developing an electrochemical sensor device to perform routine analysis of ephedrine
Template and target information: ephedrine