MIPdatabase
Authors: Abdel-Haleem FM, Madbouly A, El Nashar RM, Abdel-Ghani NT
Article Title: Molecularly imprinted polymer-based bulk optode for the determination of itopride hydrochloride in physiological fluids.
Publication date: 2016
Journal: Biosensors and Bioelectronics
Volume: 85
Page numbers: 740-742.
DOI: 10.1016/j.bios.2016.05.081
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0956566316305115
Abstract: We report here for the first time on the use of Molecularly Imprinted Polymers as modifiers in bulk optodes, Miptode, for the determination of a pharmaceutical compound, itopride hydrochloride as an example in a concentration range of 1 x 10-1 - 1 x 10-4 mol L-1. In comparison to the optode containing the ion exchanger only (Miptode 3), the optode containing the ion exchanger and the MIP particles (Miptode 2) showed improved selectivity over the most lipophilic species, Na+ and K+, by more than two orders of magnitude. For instance, the optical selectivity coefficients using Miptode 2, log K IP , J + = opt , were as follow: NH4+ < -6; Na+ = -4.0 , which were greatly enhanced in comparison with that obtained by Miptode 3. This work opens a new avenue for using miptodes for the determination of all the pharmaceutical preparations without the need for the development of new ionophores
Template and target information: itopride hydrochloride
Author keywords: molecularly imprinted polymer, Bulk optode, Itopride hydrochloride, Miptode
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