MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Yang KG, Li SW, Liu JX, Liu LK, Zhang LH, Zhang YK
Article Title: Multiepitope Templates Imprinted Particles for the Simultaneous Capture of Various Target Proteins.
Publication date: 2016
Journal: Analytical Chemistry
Volume: 88
Issue: (11)
Page numbers: 5621-5625.
DOI: 10.1021/acs.analchem.6b01247

Abstract: To achieve the simultaneous capture of various target proteins, the multiepitope templates imprinted particles were developed by phase inversion-based poly(ether sulfone) (PES) self-assembly. Herein, with the top three high-abundance proteins in the human plasma, serum albumin, immunoglobulin G, and transferrin, as the target proteins, their N-terminal peptides were synthesized as the epitope templates. After the preorganization of three epitopes and PES in dimethylacetamide, the multiepitope templates imprinted particles were formed in water through self-assembly, by which the simultaneous recognition of three target proteins in human plasma was achieved with high selectivity. Furthermore, the binding kinetics study proved that the adsorption mechanism in this imprinting system toward three epitope templates was the same as that on the single-epitope imprinting polymer. These results demonstrate that our proposed multiepitope templates imprinting strategy might open a new era of artificial antibodies to achieve the recognition of various targets simultaneously
Template and target information: protein, epitope, multiepitope imprinting, human serum albumin, immunoglobulin G, transferrin


  Periodic table Teacher shirt  MIPs peptide mug  We need to talk about Kelvin shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner