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Reference type: Journal
Authors: Wang L, Yan HY, Yang CL, Li Z, Qiao FX
Article Title: Synthesis of mimic molecularly imprinted ordered mesoporous silica adsorbent by thermally reversible semicovalent approach for pipette-tip solid-phase extraction-liquid chromatography fluorescence determination of estradiol in milk.
Publication date: 2016
Journal: Journal of Chromatography A
Volume: 1456
Page numbers: 58-67.
DOI: 10.1016/j.chroma.2016.06.010
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0021967316307543

Abstract: A mimic molecularly imprinted ordered mesoporous silica (MIOMS) adsorbent was prepared utilizing a thermally reversible semicovalent approach. The thermally reversible covalent template-monomer complex was firstly synthesized by employing 4,4'-sulfonyldiphenol (BPS) and (3-isocyanatopropyl) triethoxysilane (ICPTES) as template and monomer, respectively. The template-monomer complex was incorporated into ordered mesoporous silica via a simple self-assembly process. The adsorption experiment illustrated that the imprint-removed silica (MIOMS-ir) had higher special recognition ability (250 μg g-1) for estradiol (E2) than the non-imprinted silica (NIOMS-ir) (25 μg g-1). MIOMS-ir was applied as an adsorbent in pipette-tip solid-phase extraction (PT-SPE) coupled with liquid chromatography-fluorescence detector (LC-FLD) for determination of E2 in milk samples. Under the optimized conditions, only 3 mg of the adsorbent, 0.3 mL of water as washing solvent, and 0.5 mL of acetonitrile-acetic acid (96:4, v/v) as elution solvent were used in the pretreatment procedure of milk samples. Good calibration linearity was obtained in a range of 25 ng L-1 to 1000 ng L-1, and the recoveries at three spiked levels were ranged from 95.4% to 107.0% with relative standard deviations (RSDs) 3.1% (n = 3). The proposed MIOMS-ir-PT-SPE-LC-FLD method combined the advantages of PT-SPE and ordered mesoporous material such as ease assembly, low cost, high extraction efficiency and large specific surface area, so it is a potential pretreatment strategy for the extraction and determination of E2 in complex milk samples
Template and target information: 4,4'-sulfonyldiphenol, BPS, dummy template, estradiol, E2
Author keywords: Mimic molecular imprinting, Ordered mesoporous silica, Pipette-tip solid-phase extraction, estradiol, Milk samples

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