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Abstract: In this study, simple, effective and general processes were used for the synthesis of a new nano-molecularly imprinted polymers (MIPs) layer on magnetic Fe3O4 nanoparticles (NPs) with uniform core-shell structure by combining surface imprinting and nanotechniques. The first step for the synthesis of magnetic NPs was co-precipitation of Fe2+ and Fe3+ in an ammonia solution. Then, an SiO2 shell was coated on the magnetic core with the Stöber method. Subsequently, the C=C groups were grafted onto the silica-modified Fe3O4 surface by 3-(trimethoxysilyl) propyl methacrylate. Finally, MIPs films were formed on the surface of Fe3O4@SiO2 by the copolymerization of C=C end groups with methacrylic acid (functional monomer), ethylene glycol dimethacrylate (cross-linker), 2,2-azobisisobutyronitrile (initiator) and tizanidine (template molecule). The products were characterized using techniques that included Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), thermo gravimetric analysis (TGA), scanning electron microscopy (SEM), UV spectrophotometry, transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). Measurement of tizanidine through use of the core-shell magnetic molecularly imprinted polymers nanoparticles (MMIPs-NPs) in human plasma samples compared to the paracetamol showed that the synthesized nanosized MMIP for tizanidine has acted selectively
Template and target information: tizanidine
Author keywords: magnetic nanoparticles, Molecularly imprinted polymers, tizanidine, paracetamol, human plasma