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Abstract: Magnetite (Fe3O4 nanoparticles (NPs)) HKUST-1 metal organic framework (MOF) composite as a support was used for surface imprinting of gallic acid imprinted polymer (HKUST-1-MOF-Fe3O4-GA-MIP) using vinyltrimethoxysilane (VTMOS) as the cross-linker. Subsequently, HKUST-1-MOF-Fe3O4-NPs-GA-MIP characterized by FT-IR, XRD and FE-SEM analysis and applied for fast and selective and sensitive ultrasound assisted dispersive magnetic solid phase microextraction of gallic acid (GA) by UV-Vis (UA-DMSPME-UV-Vis) detection method. Plackett-Burman design (PBD) and central composite design (CCD) according to desirability function (DF) indicate the significant variables among the extraction factors vortex (mixing) time (min), sonication time (min), temperature (-¦C), eluent volume (L), pH and HKUST-1-MOF-Fe3O4-NPs-GA-MIP mass (mg) and their contribution on the response. Optimum conditions and values correspond to pH, HKUST-1-MOF-Fe3O4-NPs-GA-MIP mass, sonication time and the eluent volume were set as follow 3.0, 1.6 mg, 4.0 min and 180 [++L, respectively. The average recovery (ER%) of GA was 98.13% with desirability of 0.997, while the present method has best operational performance like wide linear range 8-6000 ng mL-1 with a Limit of detection (LOD) of 1.377 ng mL-1, limit of quantification (LOQ) 4.591 ng mL-1 and precision ( < 3.50% RSD). The recovery of GA in urine, human plasma and water samples within the range of 92.3-100.6% that strongly support high applicability of present method for real samples analysis, which candidate this method as promise for further application
Template and target information: gallic acid, GA
Author keywords: Fe3O4 nanoparticles, Gallic acid, HKUST-1 metal organic framework, molecularly imprinted polymer, UA-DMSPME-UV-Vis