Authors: Braco L
, Dabulis K
, Klibanov AM
Production of abiotic receptors by molecular imprinting of proteins.
Publication date: 1990
Journal: Proceedings of the National Academy of Sciences of the United States of America
Alternative URL: http://links.jstor.org/sici?sici=0027-8424%28199001%2987%3A1%3C274%3APOARBM%3E2.0.CO%3B2-B
Abstract: When a protein is dissolved in a concentrated aqueous solution of a multifunctional organic compound, freeze-dried, and washed with an anhydrous organic solvent to remove the ligand, the resultant "imprinted" protein preparation binds up to 30-fold more of the template compound in anhydrous solvents than the nonimprinted protein in the same solvent (and both proteins in water) . These artificial receptors exhibit marked ligand selectivity as well as stability in anhydrous media . This phenomenon of molecular imprinting, demonstrated for several unrelated proteins and ligands, may be helpful in the development of unique bioadsorbents and, potentially, new biocatalysts .
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