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Abstract: The molecularly imprinted polymers( MIPs) for N-tert-butoxycarbonyl-L-phenylalanine( Boc-L-Phe)were prepared by photo polymerization using Boc-L-Phe as template,methylacrylic acid( MAA) as functional monomer,and ethlene glycol dimethacrylate( EDMA) as crosslinker. The enantiomeric recognition performance of these MIPs in the high performance liquid chromatography( HPLC) mode was investigated. Infrared spectroscopy and1H-NMR spectroscopy were used to detect the binding sites and the recognition mechanism of MIPs. The results show that the template Boc-L-Phe and functional monomers form 1: 3 complexes before polymerization,and the interaction between MAA and Boc-L-Phe is relied on hydrogen bond. The C = O of MAA is the hydrogen bond acceptor. The amino and hydroxyl groups of Boc-L-Phe are the hydrogen bond donor. These are the binding sits between template molecule and functional monomer.;
Template and target information: N-tert-butoxycarbonyl-L-phenylalanine, Boc-L-Phe
Author keywords: molecularly imprinted technique, chiral resolution, hydrogen bonding