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Abstract: A computational approach was developed to find a suitable functional monomer to design a new molecularly imprinted polymer (MIP), based on which methacyrlic acid (MAA) was selected as a functional monomer to synthesize the molecular imprinted and non-imprinted polymers. All calculations were carried out using Gaussian 03 software based on the application of Hartree-Fock (HF) method with 6-31G (d) basis set. The performance of the MIPs prepared with different ratios of MAA was then evaluated using equilibrium rebinding assays. The MIP with the highest binding capacity was chosen as recognition material for the fabrication of new PVC sensors and their responses were compared with each other and with previously reported modifiers in literature. The addition of the ionic surfactant (TFPB) was found to have a synergistic effect on the response mechanism of the electrodes. The results of the MIP modified sensors show that they provide an improved electrode slope, wider pH range and a highly extended life time reaching 7 months compared to 2-4 weeks in case of traditional ion-exchangers reported in literature, besides, being successfully applied for measurements in biological samples
Template and target information: itopride hydrochloride
Author keywords: Computational studies, Itopride hydrochloride, molecular imprinted polymer, pharmaceutical analysis, Polyvinyl chloride electrodes