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Reference type: Journal
Authors: Martinez-Sena T, Armenta S, de la Guardia M, Esteve-Turrillas FA
Article Title: Determination of non-steroidal anti-inflammatory drugs in water and urine using selective molecular imprinted polymer extraction and liquid chromatography.
Publication date: 2016
Journal: Journal of Pharmaceutical and Biomedical Analysis
Volume: 131
Page numbers: 48-53.
DOI: 10.1016/j.jpba.2016.08.006
Alternative URL: http://www.sciencedirect.com/science/article/pii/S073170851630437X

Abstract: A selective solid-phase extraction was employed for the improvement of the determination of non-steroidal anti-inflammatory drugs (NSAIDs) in continental water and urine samples. Ketoprofen, naproxen, diclofenac, and ibuprofen were selected as target analytes due to they are the most frequently administered and consumed NSAIDs. These compounds were extracted using molecular imprinted polymers and determined by liquid chromatography with diode array (DAD), and tandem-mass spectrometry (MS-MS) detectors. Performance of DAD and MS-MS detectors was evaluated throughout this study. The obtained limits of quantification, after a 50-fold preconcentration solid-phase extraction, varied from 20 to 30 μg L-1 for DAD, and from 0.007 to 0.017 μg L-1 for MS-MS for both types of sample matrixes. Quantitative recoveries were found for blank-samples spiked at different NSAIDs concentration levels, ranging from 0.05 to 10 mg L-1 for urine and from 0.5 to 500 μg L-1 for water. The proposed methodology was applied for the determination of NSAID residues in urine of prescribed individuals, and continental waters
Template and target information: commercial MIP, non-steroidal anti-inflammatory drugs, NSAIDs, ketoprofen, naproxen, diclofenac, ibuprofen
Author keywords: Non-steroidal anti-inflammatory drugs, molecular imprinted polymers, liquid chromatography, urine, environmental water


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