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Reference type: Journal
Authors: Vergara AV, Pernites RB, Tiu BDB, de Leon ACC, Mangadlao JD, Binag CA, Advincula RC
Article Title: Capacitive Detection of Morphine via Cathodically Electropolymerized, Molecularly Imprinted Poly(p-aminostyrene) Films.
Publication date: 2016
Journal: Macromolecular Chemistry And Physics
Volume: 217
Issue: (16)
Page numbers: 1810-1822.
DOI: 10.1002/macp.201600127

Abstract: Highly sensitive and selective detection of morphine is exhibited using a capacitive transducer coated with cathodically electropolymerized and molecularly imprinted poly(p aminostyrene). Through molecular imprinting, morphine-specific recognition sites have been fabricated throughout the film, which shows exceptional binding activity toward morphine based from electrochemical capacitance measurements. The thin film sensor has a linear response to morphine solutions with 20-40 x 10-6 m concentrations and a detection limit of 5.95 x 10-6 m. It demonstrates high selectivity toward morphine as compared to other analog molecules including nicotine and cholesterol. The formation of the polymer film is facilitated and monitored using electrochemical-quartz crystal microbalance and characterized by X-ray photoelectron spectroscopy. Infrared spectroscopy confirms the loading and removal of the analyte from the film. Based on molecular modeling calculations, strong hydrogen-bonding interactions between the monomer, cross-linker, and analyte form a stable pre-polymerization complex, which is critical in successfully imprinting morphine into the film and effective sensing of the analyte
Template and target information: morphine
Author keywords: capacitive detection, electropolymerization, molecular imprinting, morphine, p-Aminostyrene

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