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Reference type: Journal
Authors: Cenci L, Guella G, Andreetto E, Ambrosi E, Anesi A, Bossi AM
Article Title: Guided folding takes a start from the molecular imprinting of structured epitopes.
Publication date: 2016
Journal: Nanoscale
Volume: 8
Issue: (34)
Page numbers: 15665-15670.
DOI: 10.1039/C6NR03467E

Abstract: A biomimetic route towards assisted folding was explored. Molecularly imprinted polymeric nanoparticles (MIP NPs), i.e. biomimetics with entailed molecular recognition properties made by a template assisted synthesis, were prepared to target a structured epitope: the cystine containing peptide CC9ox, which corresponds to the apical portion of the β-hairpin hormone Hepcidin-25. The structural selection was achieved by the MIP NPs; moreover, the MIP NPs demonstrated favouring the folding of the linear random peptide (CC9red) into the structured one (CC9ox), anticipating the future role of the MIP NPs as in situ nanomachines to counteract folding defects
Template and target information: peptide, hepcidin-25

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