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Reference type: Journal
Authors: Brady PA, Sanders JKM
Article Title: Selection approaches to catalytic systems.
Publication date: 1997
Journal: Chemical Society Reviews
Volume: 26
Issue: (5)
Page numbers: 327-336.
DOI: 10.1039/CS9972600327

Abstract: The key feature of enzymic catalysis is recognition of the transition state, Synthesis of designed systems rarely leads to successful catalysts as the rules for conformation and intermolecular interactions are too imperfectly understood, This review describes several current 'selection' approaches to the generation of systems that can recognise transition. state analogues, Examples covered include catalytic antibodies, ribozymes, imprinted polymers, combinatorial chemistry, and thermodynamic templating. All have the potential to yield effective catalysts without prior design of every detail

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