Authors: Wang JF
, Zhou LM
, Liu XL
, Wang JD
, Shang ZH
Simultaneous chiral separation of two pairs of enantiomers using series column of molecular imprinted phase.
Publication date: 2000
Journal: Chinese Journal of Analytical Chemistry
Alternative URL: http://en.cnki.com.cn/Article_en/CJFDTotal-FXHX200009009.htm
Abstract: Molecular imprinting polymers (MIPs) against N-Cbz-L-Ser and N- Cbz-L-Ala utilizing acrylamide plus 2-vinylpyridine as combined basic functional monomers were prepared and evaluated by high- performance liquid chromatography. MIPs showed chiral separation ability to the imprinted enantiomers and those with similar structure. Simultaneous chiral separations of N-Cbz-DL- Ser and N-Cbz-DL-Ala were achieved on a series column by connecting N-Cbz-L-Ser imprinted column and N-Cbz-L-Ala imprinted column. It showed great potential application of molecular imprinted chiral stationary in chiral separation of phamarceuticals and their intermediates
Template and target information: N-Cbz-L-Ser, N-Cbz-L-Ala
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