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Reference type: Journal
Authors: Zuo JJ, Zhao XY, Ju XC, Qiu S, Hu WS, Fan T, Zhang JK
Article Title: A New Molecularly Imprinted Polymer (MIP)-based Electrochemical Sensor for Monitoring Cardiac Troponin I (cTnI) in the Serum.
Publication date: 2016
Journal: Electroanalysis
Volume: 28
Issue: (9)
Page numbers: 2044-2049.
DOI: 10.1002/elan.201600059

Abstract: A novel molecularly imprinted polymer (MIP) sensor for rapid determination of cardiac troponin (cTnI) was established. Since it can bind to the template molecule cTnI specifically, it can be used to detect concentration of cTnI in serum without much sample pretreatment. What's more, the electrochemical signals depend on the concentration of template molecules. The synthetic sensor possesses advantages including simplicity, high specificity, low cost of preparation, good chemical and mechanical properties, sensitive and label-free determination. The synthetic sensor shows good dynamic linearity at concentration range from 0.05 to 5.00 nM. The limit of detection (LOD) was found to be 0.027 nM. The detection time of whole process was within 5 minutes
Template and target information: cardiac troponin I, cTnI
Author keywords: MIP biosensor, electro-polymerization, cardiac troponin I, O-Aminophenol, Serum sample


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