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Abstract: Molecularly imprinted particles with surface grafted functional polymer brushes were synthesized and evaluated aiming at the targeting of 5-fluorouracil (5-FU). A molecular imprinting material for 5-FU was prepared through precipitation crosslinking polymerization, in the presence of a RAFT agent, and choosing either methacrylic acid (MAA) or 2-hydroxyethyl methacrylate (HEMA) as functional monomers. In a later step, different kinds of functional polymer brushes, namely poly(methacrylic acid), poly(2-hydroxyethyl methacrylate) and poly(N-isopropylacrylamide) were grafted in the particles through a "grafting from" process starting on the RAFT groups present in their surface. The accomplishment of 5-FU imprinting was proven through comparative drug uptake measurements with imprinted/non-imprinted materials. Enhancement of 5-FU release in alkaline conditions comparatively to acidic environments was shown for particles with different combinations of molecular imprinting and grafted functional brushes. The MAA imprinting system with PMAA grafted functional brushes shows the highest improvement in 5-FU release triggered by a pH change from 2 to 10. Furthermore, for particles with PNIPA grafted brushes, a boost in drug release was also shown at T = 20 °C as compared to 40 °C. The novel achievements reported here put into evidence the combined benefits of molecularly imprinted particles with surface grafted functional polymer brushes concerning molecular recognition and stimulated 5-FU release
Template and target information: 5-fluorouracil, 5-FU
Author keywords: molecular imprinting, Functional brushes, grafting, RAFT polymerization, Drug release