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Abstract: This study reports a new molecularly imprinted polymer (MIP) for selective recognition to acetylsalicylic acid (ASA) by a non-covalent imprinting process. ASA being part of the non-steroidal anti-inflammatory drugs (NSAIDs) is also known as aspirin. Due to human excretion of the drug and its metabolites, persistent environmental contamination of ASA occurs. This requires highly efficient sorbents which permit the isolation of such pharmaceuticals from wastewater. In this regard, we synthesized a MIP by a simple thermal bulk polymerization method using acrylamide (AA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker. In order to determine the binding capacity of the new polymer several adsorption studies using different solvents were performed. Fitting of the data points with a Langmuir isotherm revealed a maximum adsorption capacity of 328.6 mg g-1 polymer in water at pH 3. It was observed that the present MIP allowed the simultaneous isolation of ASA and salicylic acid (SA), its major metabolite. This is a main advantage as both, ASA and SA can be isolated in a single extraction step. In a further experiment, the adsorption performance of the imprinted polymer was evaluated and compared to the non-imprinted polymer (NIP) and provided higher capacity values for the MIP. To check the ability of reusability, the polymer was loaded with standard solutions for several times and the percentage of removal was calculated after each treatment. Finally, the applicability of the polymer for the isolation of ASA was investigated for river water as a more complex sample
Template and target information: acetylsalicylic acid, ASA
Author keywords: molecularly imprinted polymer, Acetylsalicylic acid, Pharmaceuticals removal, water treatment