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Reference type: Journal
Authors: Hashim SNNS, Schwarz LJ, Danylec B, Mitri K, Yang YZ, Boysen RI, Hearn MTW
Article Title: Recovery of ergosterol from the medicinal mushroom, Ganoderma tsugae var. Janniae, with a molecularly imprinted polymer derived from a cleavable monomer-template composite.
Publication date: 2016
Journal: Journal of Chromatography A
Volume: 1468
Page numbers: 1-9.
DOI: 10.1016/j.chroma.2016.09.004
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0021967316311682

Abstract: A semi-covalent imprinting strategy has been developed for the synthesis of molecularly-imprinted polymers specific for the fungal sterol, ergosterol, a biological precursor of vitamin D2. This imprinting approach involved a novel post-synthesis cleavable monomer-template composite, namely ergosteryl methacrylate, and resulted in the formation of an imprinted polymer that selectively and efficiently recognized ergosterol through non-covalent interactions. The derived molecularly-imprinted polymer and the corresponding non-imprinted polymer were systematically evaluated for their selectivity towards ergosterol via static and dynamic binding studies using various ergosteryl esters (e.g. ergosteryl-cinnamate, -ferulate, -coumarate, -ferulate acetate and -acetate, respectively) as competitors. Moreover, the binding capacity of the molecularly imprinted polymer for ergosterol was enhanced when the sample loading conditions involved the use of partially aqueous solvent mixtures, such as acetonitrile/water (9:1 (v/v) or 8:2 (v/v)). These attributes were exploited in a solid-phase extraction format, whereby ergosterol was obtained with excellent recoveries from an extract of the fruiting body powder of the medicinal fungus Ganoderma tsugae var. Janniae
Template and target information: ergosterol, ergosterol methacrylate
Author keywords: Ergosterol, Ergosteryl esters, Molecularly imprinted polymers, Semi-covalent molecular imprinting, Solid-phase extraction, Sterol competitors


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