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Authors: Peng J, Tang F, Zhou R, Xie X, Li SW, Xie FF, Yu P, Mu LL
Article Title: New techniques of on-line biological sample processing and their application in the field of biopharmaceutical analysis.
Publication date: 2016
Journal: Acta Pharmaceutica Sinica B
Volume: 6
Issue: (6)
Page numbers: 540-551.
DOI: 10.1016/j.apsb.2016.05.016
Alternative URL: http://www.sciencedirect.com/science/article/pii/S2211383516300697
Abstract: Biological sample pretreatment is an important step in biological sample analysis. Due to the diversity of biological matrices, the analysis of target substances in these samples presents significant challenges to sample processing. To meet these emerging demands on biopharmaceutical analysis, this paper summarizes several new techniques of on-line biological sample processing: solid phase extraction, solid phase micro-extraction, column switching, limited intake filler, molecularly imprinted solid phase extraction, tubular column, and micro-dialysis. We describe new developments, principles, and characteristics of these techniques, and the application of liquid chromatography-mass spectrometry (LC-MS) in biopharmaceutical analysis with these new techniques in on-line biological sample processing
Template and target information: Review - online sampling in biopharmaceutical analysis
Author keywords: Biological sample pretreatment, solid phase micro-extraction, column, Turbulent flow chromatography, Restricted access material, Molecular imprinting solid phase extraction
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