Abstract: A combination strategy of moderate self-polymerization and assembly technique was proposed to fabricate superparamagnetic surface imprinted nanocomposites (SSINs) for efficient protein recognition. Homogeneous Fe3O4/Poly (methyl methacrylate) (PMMA)/Poly (dihydroxyphenylacetic acid) (PDOPA) SSINs were obtained via self-polymerization of DOPA on the surface of Fe3O4/PMMA nanospheres in the presence of lysozyme (Lyz) as a template. The Lyz-imprinted Fe3O4/PMMA/PDOPA SSINs possessed average diameters of 200 nm, high magnetic content, high saturation magnetization, as well as excellent specific recognition capacity toward Lyz template, exhibiting their great potential for biomacromolecular recognition
Template and target information: protein, lysozyme, Lyz
Author keywords: Magnetic composite, surface imprinting, Poly(dihydroxyphenylacetic acid) (PDOPA), Biomacromolecular recognition