Abstract: Electrochemiluminescence (ECL) analysis based on molecular imprinting technique, as a new analysis method, has made great progress in recent years. Molecular imprinted ECL analysis owns the advantages of both ECL analysis and molecular imprinting technology, namely high sensitivity, high selectivity, good controllability, easy miniaturization and simple operation, suggesting a wide range of applications in the fields of life sciences, food safety and environmental monitoring. In this review, the common ECL systems and basic ECL principles are introduced in detail, and the research advances of molecular imprinted ECL analysis are reviewed. The ECL mechanism mainly includes annihilation type ECL mechanism and co-reactant type ECL mechanism, examples based on ECL mechanism are introduced. Construction procedure, principles and performance of different types of molecular imprinted ECL analysis, including sensitivity, selectivity, detection range and stability of the established methods, are remarked extensively. The development of molecular imprinted polymers (MIPs)-based ECL analysis could be divided into three types:MIPs-ECL sensor based on solid-state light-emitting electrode, MIPs-ECL sensor based on non-solid-state light-emitting electrode and MIPs based-solid phase extraction coupled with ECL analysis. Among the three types mentioned above, the fabrication of solid-state light-emitting electrode to establish molecular imprinted ECL sensor is the most promising direction, in which the organic combination of ECL light-emitting materials and molecular imprinted material is achieved. In addition, the outlook of future development directions and trends of molecular imprinted ECL analysis are discussed.
Template and target information: Review - MIPs and electrochemiluminesence in analysis
Author keywords: molecular imprinting, Electrochemiluminescence, solid-state light-emitting electrode, solid phase extraction