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Reference type: Journal
Authors: Lai SZ, Chen CY, Ouyang XL, Qin YR, Cai CQ, Chen XM
Article Title: Rapid and efficient enantioseparation of (S)-amlodipine by surface-imprinted core-shell polymer microspheres.
Publication date: 2016
Journal: Journal of Separation Science
Volume: 39
Issue: (22)
Page numbers: 4354-4359.
DOI: 10.1002/jssc.201600850

Abstract: We present a protocol for the preparation of surface-imprinted polymer microspheres by core-shell precipitation polymerization for the enantioseparation of (S)-amlodipine. In this work, submicron mesoporous silica microspheres were prepared with gemini cationic surfactant as soft template. Molecularly imprinted polymers were coated on the silica supports with a low level of crosslinking, and the thickness of the thin-walled imprinted shell was about 45 nm. The material showed fast binding kinetics for (S)-amlodipine (within only 20 min for complete equilibrium), and the saturation adsorption capacity reached 309.2 mg/g, indicating the good accessibility of binding sites and improved mass transfer for target molecule. The imprinted microspheres exhibited an appreciable enantiomeric excess of (S)-amlodipine of 11.3% when used as a glass chromatography column for the enantioseparation of (S)-amlodipine from amlodipine besylate without extra chiral additives. The surface-imprinted materials display potentially amplification for industrial enantioseparation of (S)-amlodipine
Template and target information: (S)-amlodipine, amlopidine
Author keywords: Amlodipine, enantioseparation, Fast binding kinetics, Surface-imprinted polymers


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