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Abstract: Sample pretreatment is a fundamental and essential step in almost all analytical procedures, especially for the analysis of biological and environmental samples with complex matrix. In the past decades, with the development of hydrophilic interaction liquid chromatography (HILIC) in the separation of polar compounds, hydrophilic materials have also been extensively applied in sample pretreatment in a variety of areas, including biological, pharmaceutical, clinical, toxicological, food and environmental analysis. We provide an overview of the hydrophilic materials, both commercially available and synthesized in-house, which improve the extraction of the most polar compounds in sample pretreatment. We describe the chemical properties and extraction performance of hydrophilic materials that relate to their retention capabilities toward polar compounds. In addition, the existed problems and possible trends of hydrophilic materials for sample pretreatment in the future are proposed
Template and target information: Review - hydrophilic materials in sample pretreatment
Author keywords: HILIC, Hydrophilic material, sample pretreatment, enrichment, Polar compounds