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Reference type: Journal
Authors: Trotta F, Caldera F, Cavalli R, Soster M, Riedo C, Biasizzo M, Uccello Barretta G, Balzano F, Brunella V
Article Title: Molecularly imprinted cyclodextrin nanosponges for the controlled delivery of L-DOPA: perspectives for the treatment of Parkinson's disease.
Publication date: 2016
Journal: Expert Opinion on Drug Delivery
Volume: 13
Issue: (12)
Page numbers: 1671-1680.
DOI: 10.1080/17425247.2017.1248398

Abstract: Background: L-DOPA is an amino acid precursor to the neurotransmitter dopamine that is extensively used as a prodrug for the treatment of Parkinson's disease. However, L-DOPA is an unstable compound: when exposed to light or added to aqueous solutions, it may degrade, compromising its therapeutic properties.Methods: In this work, a new type of drug-loaded cyclodextrin-based nanosponge, obtained using molecular imprinting, is described for the prolonged and controlled release of L-DOPA. The molecularly imprinted nanosponges (MIP-NSs) were synthesized by cross-linking β-cyclodextrin with 1,1'-carbonyldiimidazole in DMF in the presence of L-DOPA as a template molecule. TGA, DSC and FTIR analyses were performed to characterize the interactions between L-DOPA and the two nanosponge structures. Quantitative NMR spectroscopy was used to determine the amount and the affinity of L-DOPA entrapped in the nanosponges. The in vitro L-DOPA release kinetics from the NSs were quantitatively determined by HPLC analysis.Results: The MIP-NSs show a slower and more prolonged release profile than the non-imprinted nanosponges. No degradation of the L-DOPA hosted in the MIP-NSs was observed after long-term storage at room temperature.Conclusions: The MIP-NSs are a promising alternative for the storage and controlled delivery of L-DOPA
Template and target information: L-DOPA
Author keywords: cyclodextrins, Molecularly imprinted polymers, L-DOPA, inclusion compounds, Nanosponges, in vitro release studies


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