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Abstract: A supersensitive molecular imprinting polymer (MIP) electrochemical sensor based on the structure of metal organic frameworks (MOFs) for detection of phenylethanolamine A (PEA) in swine urine samples was developed. In this sensor, PEA was used as template, p-aminothiophenol was selected as functional monomer and organic ligand, and Au nanoparticles were used as metal center to fabricate a composite membrane with molecular recognition property on gold electrode by in situ electrochemical polymerization. The characterizations of modified electrode were performed with electrochemical platform and scanning electronic microscope. The analytical conditions including scan rate, pH, elution time and incubation time and so on were optimized. Under the optimum conditions, the limit of the developed MOFs-MIP electrochemical sensor for the detection for PEA was as low as 1.0 x 10-13 mol/L and the linear rang was from 1.0 x 10-13 to 1.0 x 10-9 mol/L with correlation coefficient of 0.996. The recoveries of PEA were from 92.7% to 108.4% under different spiked levels of PEA in animal urine and the relative standard deviation (RSD) was below 8.0%. The developed method possessed many advantages such as high sensitivity, specificity and stability.
Template and target information: phenylethanolamine A, PEA