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Abstract: Using gatifloxacin (GTFX) as template molecule, magnetic surface molecularly imprinted polymers (M-MIPs) were prepared on the surface of modified magnetic silica (Fe3O4@SiO2) with surface molecular imprinting technique. The polymers were characterized by transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM). The static adsorption experiments and Scatchard analysis suggested that there were two types of binding sites in the M-MIPs. The maximum adsorption capacities of M-MIPs and magnetic non-imprinted polymers (M-NIPs) for GTFX were 35.1 mg/g and 23.1 mg/g, respectively. The selectivity coefficients of GTFX M-MIPs to ciprofloxacin (CPFX), norfloxacin (NFLX), melamine (MEL) and tetracycline (TC) were 2.43, 5.18, 6.61 and 12.99, and the relative selectivity coefficients of M-MIPs to M-NIPs for these four drugs were 2.09, 1.95, 3.15 and 2.43, respectively, indicating the good specific recognition capability for GTFX. Combined with high performance liquid chromatographic analysis, the M-MIPs were applied to extract and enrich GTFX in milk sample with the recoveries more than 91.5%.
Template and target information: gatifloxacin, GTFX
Author keywords: Magnetic silica, Gatifloxacin, surface molecularly imprinted polymers, adsorption